Green tea extract EGCG reduces size of uterine fibroids.
Yes it is green tea extract EGCG again. An amazing antioxidant that does much more than protect us from the free radical oxidative damage we read so much about. In this interesting study Women find that a daily 800 mg supplementation of EGCG for a 4 months reduced the volume of uterine fibroids aswell as reducing symptoms such as heavy bleeding. Uterine fibroids are not easy to eliminate and it takes time to reduce size. In many cases surgery may be recommended and this is fine except it does not change what was happening in the body to cause fibroid growth. As with all chronic conditions we look at the whole person and what is happening in their body. I will prescribe Chinese herbs because they are excellent at disrupting the pathways involved in fibroid growth. It is also necessary to look at estrogen levels and what environmental factors maybe creating high levels of estrogen. Estrogen metabolism could also be impaired and if so this will need to be corrected. However adding EGCG could it seems improve outcomes as this great study below reports. However we must be cautious with EGCG’s may affect iron absorption. Studies have found that green tea inhibits iron absorption.
Roshdy E, Rajaratnam V, Maitra S, Sabry M, Allah ASA, Al-Hendy A. Treatment of symptomatic uterine fibroids with green tea extract: a pilot randomized controlled clinical study. International Journal of Women’s Health. 2013;5:477-486. doi:10.2147/IJWH.S41021.
Uterine fibroids (UFs, also known as leiomyoma) affect 70% of reproductive-age women. Imposing a major burden on health-related quality-of-life (HRQL) of premenopausal women, UF is a public health concern. There are no effective medicinal treatment options currently available for women with symptomatic UF.
To evaluate the efficacy and safety of green tea extract (epigallocatechin gallate [EGCG]) on UF burden and quality of life in women with symptomatic UF, in a double-blinded, placebo-controlled randomized clinical trial.
A total of 39 reproductive-age women (age 18–50 years, day 3 serum follicle-stimulating hormone <10 \U/mL) with symptomatic UF were recruited for this study. All subjects had at least one fibroid lesion 2 cm3 or larger, as confirmed by transvaginal ultrasonography. The subjects were randomized to oral daily treatment with either 800 mg of green tea extract (45% EGCG) or placebo (800 mg of brown rice) for 4 months, and UF volumes were measured at the end, also by transvaginal ultrasonography. The fibroid-specific symptom severity and HRQL of these UF patients were scored at each monthly visit, using the symptom severity and quality-of-life questionnaires. Student’s t-test was used to evaluate statistical significance of treatment effect between the two groups.
Of the final 39 women recruited for the study, 33 were compliant and completed all five visits of the study. In the placebo group (n = 11), fibroid volume increased (24.3%) over the study period; however, patients randomized to green tea extract (n = 22, 800 mg/day) treatment showed significant reduction (32.6%, P = 0.0001) in total UF volume. In addition, EGCG treatment significantly reduced fibroid-specific symptom severity (32.4%, P = 0.0001) and induced significant improvement in HRQL (18.53%, P = 0.01) compared to the placebo group. Anemia also significantly improved by 0.7 g/dL (P = 0.02) in the EGCG treatment group, while average blood loss significantly decreased from 71 mL/month to 45 mL/month (P = 0.001). No adverse effects, endometrial hyperplasia, or other endometrial pathology were observed in either group.
EGCG shows promise as a safe and effective therapeutic agent for women with symptomatic UFs. Such a simple, inexpensive, and orally administered therapy can improve women’s health globally.